NF-κB Inhibitor, SN50 | 2506

This peptide contains the nuclear localization sequence (NLS residues 360-369) of the transcription factor NF-κB p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). SN50 inhibits translocation of the NF-κB active complex into the nucleus. In mouse endothelial LE-II cells induced with LPS, inhibition of NF-κB nuclear translocation was 88% at 50 µg/ml (18 µM). In human monocytic THP-1 cells induced by LPS or TNFα there was 85% inhibition at 100 µg/ml.

NF-κB Inhibitor, SN50 contains the nuclear localization sequence (NLS residues 360-369) of the transcription factor NF-κB p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). SN50 inhibits translocation of the NF-κB active complex into the nucleus.

2506 | NF-κB Inhibitor, SN50 DataSheet

Alternate Name/Synonyms: SN50; AAVALLPAVLLALLAPVQRKRQKLMP

Appearance: Lyophilized solid

Formulation: N/A

CAS Number: 213546-53-3

Structure Available?: No

Peptide sequence: Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH

Salt Form: TFA salt

Molecular Formula: C₁₂₉H₂₃₀N₃₆O₂₉S

Molecular Weight: 2781.5

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: H₂O

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A NF-κB Inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: N/A

InChi: N/A

InChi Key: N/A