NFAT1 polyclonal Antibody | BS90934

NFAT1 polyclonal Antibody | BS90934 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC/IF IHC FC

Application Range: WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: The NFAT (nuclear factor of activated T cells) family of transcription factors regulates cytokine expression in T cells. Members of the family include NFATc1 (NFATc), NFATc2 (NFATp), NFATn, NFATc3 (NFAT4, NFATx) and NFATc4 (NFAT3) . Recognition of antigen by the T cell receptor (TCR) eventually activates the calcium-dependent protein phosphatase calcineurin. Once activated, calcineurin stimulates the translocation of NFATc1 (cytoplasmic) from the cytoplasm to the nucleus where it associates with NFATn (nuclear) . Like NFATc1, NFATc2 resides in the cytoplasm and translocates to the nucleus subsequent to activation of calcineurin. Once in the nucleus, NFATc2 synergizes with AP-1 transcription factors to initiate transcription of cytokine genes. NFATc3 and NFATc4 share 65% sequence identity with other members of the NFAT family. They are similar to NFATc2 in that they also synergize with the AP-1 family of proteins.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: NFAT1 polyclonal Antibody detects endogenous levels of NFAT1 protein.

Molecular Weight: 135 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NF-ATc2, NFATc2, NF-ATp, NFATC2, AI607462, cytoplasmic 2, KIAA0611, NF ATc2, NF ATp, NF-ATc2, NF-ATp, NFAC2, NFAT 1, NFAT pre existing subunit, NFAT pre-existing subunit, NFAT transcription complex, preexisting component, NFAT1, NFAT1-D, NFATc2, NFATp, Nuclear factor of activated T cells cytoplasmic 2, Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2, Nuclear factor of activated T cells pre-existing component, Nuclear factor of activated T cells, preexisting component, Nuclear factor of activated T-cells, Preexisting nuclear factor of activated T cells 2, T cell transcription factor NFAT 1, T-cell transcription factor NFAT1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: ESC Pluripotency and Differentiation Signaling Pathway,