NFE4 Antibody (Center) [APR33178G]

NFE4 Antibody (Center) [APR33178G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NFE4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 102-136 amino acids from the Central region of human NFE4.

Cellular Localisation: Nucleus.

Molecular Weight: 19019

Clone: Polyclonal

Gene Name: NFE4

Gene ID: 58160

Function: Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR) . The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter.

Summary: Tissue Location: Specifically expressed in fetal liver, cord blood and bone marrow. Also expressed in the K562 and HEL cell lines, which constitutively express the fetal globin genes

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Transcription factor NF-E4, NFE4