NFkB p100 / p52 Antibody | 19-737

NFkB p100 / p52 Antibody | 19-737 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: A synthetic peptide of human NFkB p100 / p52

Research Area: Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction, Transcription

Tested Application: WB, IHC, IF

Application: WB: 1:500 - 1:1000
IHC: 1:50 - 1:100
IF: 1:50 - 1:200

Specificiy: N/A

Positive Control 1: HT-29

Positive Control 2: A-549

Positive Control 3: HeLa

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 33kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: NFKB2, p52, p105, H2TF1, LYT10, CVID10, LYT-10, NF-kB2

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB) . The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.