NGFR Antibody [AMM22108G]

NGFR Antibody [AMM22108G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H, M

Specificity: This NGFR antibody is generated from mouse immunized with NGFR recombinant protein.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein. Perikaryon {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z0W1}

Molecular Weight: 45183

Clone: Monoclonal

Gene Name: NGFR

Gene ID: 4804

Function: Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487) . Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity) . Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181) . Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin- dependent glucose uptake (By similarity) . Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138) .

Summary: N/A

Form: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IF, WB, IHC-P

Dilution: IF--1:100 WB--1:500~1000 IHC-P--1:100~500

Synonyms: Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271, NGFR, TNFRSF16