Niclosamide | 1826

A STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.

Niclosamide is a STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.

1826 | Niclosamide DataSheet

Alternate Name/Synonyms: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

Appearance: Off-white to pale yellow solid

Formulation: N/A

CAS Number: 50-65-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₈Cl₂N₂O₄

Molecular Weight: 327.12

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (10 mM) or Ethanol (25 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A STAT3 signaling pathway inhibitor

MDL Number: MFCD00057597

PubChem CID: 4477

SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O

InChi: InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)

InChi Key: RJMUSRYZPJIFPJ-UHFFFAOYSA-N