Nigericin sodium salt | 2096

Nigericin is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K⁺> Rb⁺ Cs⁺>> Na⁺. Also activates NLRP3/NALP3 and signals through pannexin-1 to induce caspase-1 maturation and IL-1β processing and release.

Nigericin is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K⁺> Rb⁺ Cs⁺>> Na⁺. Also activates NLRP3/NALP3 and signals through pannexin-1 to induce caspase-1 maturation and IL-1β processing and release.

2096 | Nigericin sodium salt DataSheet

Alternate Name/Synonyms: Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A; BRN 169675

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 28643-80-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₄₀H₆₇NaO₁₁

Molecular Weight: 746.94

Cell-Permeable?: No

Purity: ≥98% by TLC

Solubilities: DMSO (~50 mg/ml) or Ethanol (~20 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A polyether ionophore

MDL Number: MFCD00036825

PubChem CID: 16760591

SMILES: CC1CCC(OC1C(C)C(=O)[O-])CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC.[Na+]

InChi: InChI=1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1

InChi Key: MOYOTUKECQMGHE-PDEFJWSRSA-M