Nilotinib | 1750

A potent, selective BCR-ABL inhibitor that fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib (Cat. No. 1625-100, 1000). Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC₅₀ < 30 nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants.

Nilotinib is a potent, selective BCR-ABL inhibitor that fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib (Cat. No. 1625-100, 1000). Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC₅₀ < 30 nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants.

1750 | Nilotinib DataSheet

Alternate Name/Synonyms: 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)- 5-(trifluoromethyl)phenyl]-3- [(4-pyridin-3-ylpyrimidin-2-yl) amino]benzamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 641571-10-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₂₂F₃N₇O

Molecular Weight: 529.52

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (50 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent and selective BCR-ABL inhibitor

MDL Number: MFCD09833716

PubChem CID: 644241

SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5

InChi: InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29, 30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)

InChi Key: HHZIURLSWUIHRB-UHFFFAOYSA-N