Nimesulide | 2777

Nimesulide is a selective cyclooxygenase-2 (COX-2) inhibitor. The IC₅₀ values are 70 and 1.27 µM for human recombinant COX-1 and -2 (at 20 µM arachidonic acid), respectively, and 22 and 0.03 µM for ovine COX-1 and -2 (at 100 µM arachidonic acid), respectively.

Nimesulide is a selective cyclooxygenase-2 (COX-2) inhibitor. The IC₅₀ values are 70 and 1.27 µM for human recombinant COX-1 and -2 (at 20 µM arachidonic acid), respectively, and 22 and 0.03 µM for ovine COX-1 and -2 (at 100 µM arachidonic acid), respectively.

2777 | Nimesulide DataSheet

Alternate Name/Synonyms: N-​(4-​Nitro-​2-​phenoxyphenyl)-​methanesulfonamide; R805

Appearance: Yellow solid

Formulation: N/A

CAS Number: 51803-78-2

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₂N₂O₅S

Molecular Weight: 308.31

Cell-Permeable?: Y

Purity: ≥98%

Solubilities: DMSO (~30 mg/ml) or EtOH (~ 7 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective cyclooxygenase-2 (COX-2) inhibitor.

MDL Number: MFCD00079470

PubChem CID: 4495

SMILES: CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2

InChi: InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3

InChi Key: HYWYRSMBCFDLJT-UHFFFAOYSA-N