NIP45 polyclonal Antibody | BS62536

NIP45 polyclonal Antibody | BS62536 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: NFATc2IP (NFATc2-interacting protein), also known as NIP45, is a 419 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one ubiquitin-like domain. Interacting with NFATc2, TRAF1 and TRAF2, NFATc2IP plays a role in the inducible expression of cytokines in T-cells, specifically by enhancing NFATc2-induced interleukin (IL) production. NFATc2IP exists as three alternatively spliced isoforms and is subject to post-translational methylation; an event which augments NFATc2IP-regulated cytokine production. The gene encoding NFATc2IP maps to human chromosome 16p11.2, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn’s disease, which is a gastrointestinal inflammatory condition.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NIP45 polyclonal Antibody detects endogenous levels of NIP45 protein.

Molecular Weight: ~ 60 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NFATC2-interacting protein; 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein; NFATC2IP; NIP45

Immunogen: Synthetic peptide, corresponding to Human NIP45.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: