Nitazoxanide | B3041

Nitazoxanide is a nitrothiazole benzamide with anti-parasitic and anti-viral activity. It inhibits pyruvate-ferredoxin oxidoreductase in protozoa and anaerobic bacteria. It inhibits many anerobes in vitro, with MIC₉₀ values of 0.06 μg/ml-4 μg/ml. It inhibits different strains of influenza A virus replication with EC₅₀ values of 1, 0.5, and 1 μg/ml respectively. It is used to treat enteritis caused by Cryptosporidium parvum and Giardia lamblia in children and adults. It is in clinical trials for treatment against COVID-19.

Nitazoxanide is a nitrothiazole benzamide with anti-parasitic and anti-viral activity. It inhibits pyruvate-ferredoxin oxidoreductase in protozoa and anaerobic bacteria. It inhibits many anerobes in vitro, with MIC₉₀ values of 0.06 μg/ml-4 μg/ml. It inhibits different strains of influenza A virus replication with EC₅₀ values of 1, 0.5, and 1 μg/ml respectively. It is used to treat enteritis caused by Cryptosporidium parvum and Giardia lamblia in children and adults. It is in clinical trials for treatment against COVID-19.

B3041 | Nitazoxanide DataSheet

Alternate Name/Synonyms: Alinia; Daxon; [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate; Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-; N-(5-Nitro-2-thiazolyl)salicylamide acetate (ester); acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester; NTZ; [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] ethanoate

Appearance: White to Off-white powder

Formulation:

CAS Number: 55981-09-4

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₂H₉N₃O₅S

Molecular Weight: 307.28

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~20 mg/ml in DMSO; ~15 mg/ml in DMF

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A nitrothiazole benzamide with anti-parasitic and anti-viral activity

MDL Number: MFCD00416599

PubChem CID: 41684

SMILES: CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]

InChi: InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

InChi Key: YQNQNVDNTFHQSW-UHFFFAOYSA-N