Description
NKG2-A/C/E Antibody [20d5] (PE) | 98-950 | Gentaur UK, US & Europe Distribution
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: CHO cells transfected with B6 allele of NKG2A gene
Research Area: Immunology
Tested Application: Flow
Application: NKG2-A/C/E Antibody [20d5] for use in flow cytometry assays.
Specificiy: NKG2-A/C/E
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [20d5]
Isotype: IgG2a
Conjugate: PE
Physical State: Liquid
Buffer: Supplied in PBS/NaN3 and a stabilizing agent
Concentration: 0.1 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: NKG2A, NKG2C, NKG2E
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The monoclonal antibody 20d5 reacts with an epitope common to the NKG2A, NKG2C and NKG2E isoforms of the NKG2 heterodimer, a member of the c-type lectin family of inhibitory receptors. Mouse NKG2 is a natural killer (NK) cell receptor for the non-classical MHC class I molecule Qa-1b. NKG2 is expressed on NK cells, lymphokine-activated killer (LAK) T cells, and some CD8+ memory T cells. Two-color immunofluorescent staining with the 20d5 antibody reveals two distinct NKG2+ phenotypes within the NK1.1+CD3- spleen cell population: NKG2hi (50%) and NKG2low (50%) . With the exception of DBA/2J mice, NKG2 is expressed on NK1.1+ cells from all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL) .