NKRF Antibody (Center) [APR17581G]

NKRF Antibody (Center) [APR17581G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NKRF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-233 amino acids from the Central region of human NKRF.

Cellular Localisation: Nucleus, nucleolus.

Molecular Weight: 77673

Clone: Polyclonal

Gene Name: NKRF

Gene ID: 55922

Function: Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK- kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.

Summary: Tissue Location: Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: NF-kappa-B-repressing factor, NFkB-repressing factor, Protein ITBA4, Transcription factor NRF, NKRF, ITBA4, NRF