NKX2-5 Antibody (Center) [AMM06704G]

NKX2-5 Antibody (Center) [AMM06704G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This NKX2-5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-111 amino acids from the Central region of human NKX2-5.

Cellular Localisation: Nucleus.

Molecular Weight: 34918

Clone: Polyclonal

Gene Name: NKX2-5

Gene ID: 1482

Function: Transcription factor required for the development of the heart and the spleen (PubMed:22560297) . During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (By similarity) . May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity) . Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761) . Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297) .

Summary: Tissue Location: Expressed only in the heart.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Homeobox protein Nkx-25, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, NKX2-5, CSX, NKX25, NKX2E