NLRP3i | B2529

NLRP3i is an intermediate in the glyburide synthesis that acts as a NLRP3 inflammasome inhibitor. It inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size after myocardial ischemia-reperfusion in the mouse, without affecting glucose metabolism.

NLRP3i is an intermediate in the glyburide synthesis that acts as a NLRP3 inflammasome inhibitor. It inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size after myocardial ischemia-reperfusion in the mouse, without affecting glucose metabolism.

B2529 | NLRP3i DataSheet

Alternate Name/Synonyms: JC121, N-[2-[4-(Aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide

Appearance: White solid

Formulation:

CAS Number: 16673-34-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₇ClN₂O₄S

Molecular Weight: 368.84

Cell-Permeable?: True

Purity: ≥95%

Solubilities: >18 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A NLRP3 inflammasome inhibitor

MDL Number: MFCD00193756

PubChem CID: 85542

SMILES: COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)N

InChi: InChI=1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)

InChi Key: KVWWTCSJLGHLRM-UHFFFAOYSA-N