NMS-873 | 9600

NMS-873 is a potent, selective, allosteric inhibitor of the ATPase VCP/p97 (IC₅₀ = 30 nM). NMS-873 activates the unfolded protein response, interferes with autophagy and induces cancer cell death. NMS-873 also inhibits proliferation of HCT116 cancer cell line cells with an IC₅₀ value of 400 nM.

NMS-873 is a potent, selective, allosteric inhibitor of the ATPase VCP/p97 (IC₅₀ = 30 nM). NMS-873 activates the unfolded protein response, interferes with autophagy and induces cancer cell death. NMS-873 also inhibits proliferation of HCT116 cancer cell line cells with an IC₅₀ value of 400 nM.

9600 | NMS-873 DataSheet

Alternate Name/Synonyms: (3-​[3-​(cyclopentylthio)​-​5-​[[[2-​methyl-​4'-​(methylsulfonyl)​[1,​1'-​biphenyl]​-​4-​yl]​oxy]​methyl]​-​4H-​1,​2,​4-​triazol-​4-​yl]​-pyridine

Appearance: Off-white solid

Formulation: N/A

CAS Number: 1418013-75-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₈N₄O₃S₂

Molecular Weight: 520.67

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, selective, allosteric inhibitor of the ATPase VCP/p97

MDL Number: MFCD28009371

PubChem CID: 71521142

SMILES: CC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C

InChi: InChI=1S/C27H28N4O3S2/c1-19-16-22(11-14-25(19)20-9-12-24(13-10-20)36(2,32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6,9-17,23H,3-4,7-8,18H2,1-2H3

InChi Key: UJGTUKMAJVCBIS-UHFFFAOYSA-N