NMS-P118 | B2320

A potent, and selective poly(ADP-ribose) polymerase 1 (PARP1) inhibitor. It is selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390 nM). NMS-P118 displays anticancer activity as single agent, as well as in combination therapies.

NMS-P118 is a potent, and selective poly(ADP-ribose) polymerase 1 (PARP1) inhibitor. It is selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390 nM). NMS-P118 displays anticancer activity as single agent, as well as in combination therapies.

B2320 | NMS-P118 DataSheet

Alternate Name/Synonyms: 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide

Appearance: Crystalline solid

Formulation:

CAS Number: 1262417-51-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₀H₂₄F₃N₃O₂

Molecular Weight: 395.42

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: >20 mg/ml (DMSO) in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent, and selective poly(ADP-ribose) polymerase 1 (PARP1) inhibitor

MDL Number: N/A

PubChem CID: 49843531

SMILES: C1CC(CCC1N2CCC(CC2)N3CC4=C(C3=O)C(=CC(=C4)F)C(=O)N)(F)F

InChi: InChI=1S/C20H24F3N3O2/c21-13-9-12-11-26(19(28)17(12)16(10-13)18(24)27)15-3-7-25(8-4-15)14-1-5-20(22,23)6-2-14/h9-10,14-15H,1-8,11H2,(H2,24,27)

InChi Key: ARYVAQSYRLZVQD-UHFFFAOYSA-N