Nocodazole | 2185

A microtubule inhibitor; inhibits mitosis. Disrupts microtubules by binding to β‑tubulin and preventing formation of one of the two interchain disulfide linkages, thus inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex. Arrests the cell cycle at G2/M phase. Also inhibits autophagosome-lysosome fusion.

Nocodazole is a microtubule inhibitor; inhibits mitosis. Disrupts microtubules by binding to β‑tubulin and preventing formation of one of the two interchain disulfide linkages, thus inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex.

2185 | Nocodazole DataSheet

Alternate Name/Synonyms: 5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbonic acid, methyl ester

Appearance: Pale yelow solid

Formulation: N/A

CAS Number: 31430-18-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₁₁N₃O₃S

Molecular Weight: 301.32

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A microtubule inhibitor

MDL Number: MFCD00005588

PubChem CID: 4122

SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3

InChi: InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)

InChi Key: KYRVNWMVYQXFEU-UHFFFAOYSA-N