Nodularin | 2094

Nodularin is a hepatotoxic monocylic pentapeptide produced by cyanobacterium Nodularia spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC₅₀ values of 1.8 and 0.026 nM, respectively. It inhibits PP2B only at higher concentrations ( IC₅₀ = 1.8 µM).

Nodularin is a hepatotoxic monocylic pentapeptide produced by cyanobacterium Nodularia spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC₅₀ values of 1.8 and 0.026 nM, respectively. It inhibits PP2B only at higher concentrations ( IC₅₀ = 1.8 µM).

2094 | Nodularin DataSheet

Alternate Name/Synonyms: Cyclo[3S-​amino-​9S-​methoxy-​2S,​6E,​8S-​trimethyl-​10-​phenyl-​4,​6-​ decadienoyl-​D-​γ-​glutamyl-​(2Z)-​2-​(methylamino)-​2-​butenoyl-​(3S)-​ 3-​methyl-​D-​β-​aspartyl-​L-​arginyl]

Appearance: Liquid

Formulation: In Ethanol

CAS Number: 118399-22-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₄₁H₆₀N₈O₁₀

Molecular Weight: 824.96

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: N/A

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A)

MDL Number: MFCD16659855

PubChem CID: 6437077

SMILES: CC=C1C(=O)NC(C(C(=O)NC(C(=O)NC(C(C(=O)NC(CCC(=O)N1C)C(=O)O)C)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C)CCCN=C(N)N)C)C(=O)O

InChi: InChI=1S/C41H60N8O10/c1-8-31-38(54)48-34(40(57)58)26(5)36(52)46-29(15-12-20-44-41(42)43)37(53)45-28(25(4)35(51)47-30(39(55)56)18-19-33(50)49(31)6)17-16-23(2)21-24(3)32(59-7)22-27-13-10-9-11-14-27/h8-11,13-14, 16-17,21,24-26,28-30,32,34H,12,15,18-20,22H2,1-7H3,(H,45,53)(H,46,52)(H,47,51)(H,48,54)(H,55,56)(H,57,58)(H4,42,43,44)/b17-16+,23-21+,31-8+

InChi Key: IXBQSRWSVIBXNC-ANPQUZCZSA-N