NOS1 (phospho-S852) polyclonal Antibody | BS4274

NOS1 (phospho-S852) polyclonal Antibody | BS4274 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: NOS activity requires homodimerization as well as three cosubstrates (L-arginine, NADPH and O2) and five cofactors or prosthetic groups (FAD, FMN, calmodulin, tetrahydrobiopterin and heme) . Several distinct NOS isoforms have been described and been shown to represent the products of three distinct genes. These include two constitutive Ca2+/CaM-dependent forms of NOS, including NOS1 (also designated ncNOS) whose activity was first identified in neurons, and NOS3 (also designated ecNOS), first identified in endothelial cells.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-NOS1 (S852) polyclonal Antibody detects endogenous levels of human NOS1 protein only when phosphorylated at Ser852. This Antibody also detects mouse and rat NOS1 protein when phosphorylated at the corresponding sites (Ser847) .

Molecular Weight: ~ 43,125,149,160 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Nitric oxide synthase, brain; Constitutive NOS; NC-NOS; NOS type I; Neuronal NOS; N-NOS; nNOS; Peptidyl-cysteine S-nitrosylase NOS1; bNOS; NOS1

Immunogen: Synthetic phosphopeptide derived from human NOS1 around the phosphorylation site of Serine 852.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: PI3K AKT signaling,Protein Kinase C Signaling,Hypoxia Signaling,Translational Contral elF4 and p70 S6 Kinase,Inhibition of Apoptosis,Insulin &Glucose Signaling,MAPK Erk in Growth and Differentiation Pathway,Mitochondrial Control of Apoptosis,MTOR signaling,ErbB HER Signaling,