Notch-2, mouse recombinant | 7531

Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.

7531 | Notch-2 mouse recombinant DataSheet

Biomolecule/Target: Notch-2

Synonyms: Neurogenic Locus Notch Homolog Protein 2; Notch B

Alternates names: Neurogenic Locus Notch Homolog Protein 2; Notch B

Taglines: Protein involved in lateral inhibition in embryogenesis and multiple cellular processes through-out adulthood.

NCBI Gene ID #: 16181

NCBI Gene Symbol: IL-1RA

Gene Source: Mouse

Accession #: P25085

Recombinant: Yes

Source: CHO cells

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <0.01 EU/g purified protein

Activity (Specifications/test method): N/A

Biological activity: The mouse IL-1Ra is capable of inhibiting IL-1-alpha activity in helper T cell line D10.G4.1.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: ~87.0 kDa. The extracellular domain of mouse Notch-2 (aa 26-494) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized with PBS

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile ddHO to a concentration 100 µg/ml. This solution can then be diluted into other aqueous buffers.

Amino acid sequence: The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Cys-Arg-Pro-Ser-Gly.