NOTCH3 Antibody| F40367-0.08ML/F40367-0.4ML/R35352-100UG

NOTCH3 Antibody| F40367-0.08ML/F40367-0.4ML/R35352-100UG | Gentaur UK, US & Europe Distribution

Background: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq].

Format: Purified

Clone: 487CT6.9.2

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Isotype: Mouse IgG1

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:100-1:250

Application Note: Titration of the NOTCH3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This NOTCH3 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 2291-2321 from the human protein was used as the immunogen for this NOTCH3 antibody.

Storage: Aliquot the NOTCH3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A