Novobiocin Sodium Salt | B1526

Novobiocin is a coumarin antibiotic isolated from Streptomyces species, that inhibits the ATPase activity of DNA gyrase. Its antibacterial activity arises from competitive inhibition of the ATPase reaction catalyzed by the GyrB subunit. In addition to permitting relaxation of negative supercoils, novobiocin has been used to generate positively supercoiled DNA. It has also been shown to inhibit the chaperone activity of Hsp90 as well as acting as an inhibitor of DNA Topoisomerase II.

Novobiocin is a coumarin antibiotic isolated from Streptomyces species, that inhibits the ATPase activity of DNA gyrase. Its antibacterial activity arises from competitive inhibition of the ATPase reaction catalyzed by the GyrB subunit. In addition to permitting relaxation of negative supercoils, novobiocin has been used to generate positively supercoiled DNA. It has also been shown to inhibit the chaperone activity of Hsp90 as well as acting as an inhibitor of DNA Topoisomerase II.

B1526 | Novobiocin Sodium Salt DataSheet

Alternate Name/Synonyms: Albamycin; Cathomycin sodium; NSC-2382

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1476-53-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₃₁H₃₅N₂NaO₁₁

Molecular Weight: 634.61

Cell-Permeable?: Yes

Purity: ≥90%

Solubilities: H₂O (~50 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An inhibitor of bacterial DNA gyrase

MDL Number: MFCD00066541

PubChem CID: 54730021

SMILES: CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)[O-])CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]

InChi: InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q;+1/p-1

InChi Key: WWPRGAYLRGSOSU-UHFFFAOYSA-M