Description
Novobiocin is a coumarin antibiotic isolated from Streptomyces species, that inhibits the ATPase activity of DNA gyrase. Its antibacterial activity arises from competitive inhibition of the ATPase reaction catalyzed by the GyrB subunit. In addition to permitting relaxation of negative supercoils, novobiocin has been used to generate positively supercoiled DNA. It has also been shown to inhibit the chaperone activity of Hsp90 as well as acting as an inhibitor of DNA Topoisomerase II.
Novobiocin is a coumarin antibiotic isolated from Streptomyces species, that inhibits the ATPase activity of DNA gyrase. Its antibacterial activity arises from competitive inhibition of the ATPase reaction catalyzed by the GyrB subunit. In addition to permitting relaxation of negative supercoils, novobiocin has been used to generate positively supercoiled DNA. It has also been shown to inhibit the chaperone activity of Hsp90 as well as acting as an inhibitor of DNA Topoisomerase II.
B1526 | Novobiocin Sodium Salt DataSheet
Alternate Name/Synonyms: Albamycin; Cathomycin sodium; NSC-2382
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1476-53-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₃₁H₃₅N₂NaO₁₁
Molecular Weight: 634.61
Cell-Permeable?: Yes
Purity: ≥90%
Solubilities: H₂O (~50 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: An inhibitor of bacterial DNA gyrase
MDL Number: MFCD00066541
PubChem CID: 54730021
SMILES: CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)[O-])CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]
InChi: InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q;+1/p-1
InChi Key: WWPRGAYLRGSOSU-UHFFFAOYSA-M
Additional Information
Storage Condition: |
+4°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |