NOX4 polyclonal Antibody | BS90957

NOX4 polyclonal Antibody | BS90957 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC IHC IP

Application Range: WB:1:1,000 ICC:1:50-1:100 IHC:1:50-1:200

Background: The superoxide-generating NADPH oxidase includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome, cytochrome b558, to form the active enzyme complex. The p22 and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Nox4 (also known as Renox) is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. Nox4 is also expressed in fetal tissues, placenta, glioblastoma and vascular cells. Like gp91-phox, the enzymatic activity of Nox4 produces superoxide anions. In vascular cells, the addition of Angiotensin II increases Nox4 expression, which suggests a role for Nox4 in vascular oxidative stress response. The gene encoding human Nox4 maps to chromosome 11q14.2-q21.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: NOX4 polyclonal Antibody detects endogenous levels of NOX4 protein.

Molecular Weight: 67 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: KOX-1, NOX4, RENOX, Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, KOX 1, KOX, Kox-1, NADPH, NADPH oxidase 4, Nox4, NOX4, Renal NAD (P) H-oxidase, RENOX,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: