NPLOC4 Antibody (C-term) [APR17590G]

NPLOC4 Antibody (C-term) [APR17590G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NPLOC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-484 amino acids from the C-terminal region of human NPLOC4.

Cellular Localisation: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ES54}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9ES54}. Nucleus {ECO:0000250|UniProtKB:Q9ES54} Note=Associated with the endoplasmic reticulum and nuclear {ECO:0000250|UniProtKB:Q9ES54}

Molecular Weight: 68120

Clone: Polyclonal

Gene Name: NPLOC4

Gene ID: 55666

Function: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) . Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729) .

Summary: Tissue Location: Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Nuclear protein localization protein 4 homolog, Protein NPL4, NPLOC4, KIAA1499, NPL4