Description
NQO1 is a cytosolic antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites and their derivatives by using NAD (P)H as an electron donor. Thus NQO1 acts as a detoxifying enzyme and is involved in the bodys protection against oxidative stress. NQO1 acts as a protein chaperone, one of its targets being p53. In humans NQO1 is expressed at high levels in adipocytes and its expression levels are positively correlated with adiposity, glucose tolerance, and makers of liver dysfunction. Altered expression of NQO1 is associated with Alzheimers disease. NQO1 is abnormally elevated in many types of solid tumors and may represent a useful biomarker of pancreatic cancer.
7571 | NQO1 human recombinant DataSheet
Biomolecule/Target: NQO1
Synonyms: NAD(P)H Dehydrogenase (Quinine) 1 (NQO1); Quinone Reductase 1 (QR1); DT-Diaphorase (DTD); Azoreductase; Phylloquinone Reductase; Menadione Reductase; Dioxin-inducible 1; Disphorase-4 (DIA4); NAD(P)H Quinone Oxireductase; Quinone Oxidoreductase 1
Alternates names: Protein L
Taglines: Catalyzes the reduction of highly reactive quinone metabolites and their derivatives
NCBI Gene ID #: N/A
NCBI Gene Symbol: N/A
Gene Source: Peptostreptococcus Magnus
Accession #: CAA25612
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: <0.1 ng/g
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 43.2 kDa with 5 IgG binding sites
Concentration: N/A
Appearance: Liquid
Physical form description: Lyophilized with no additives
Reconstitution Instructions: Reconstitution in HO to a concentration of 5 mg/ml gives a clear solution.
Amino acid sequence: N/A