NRBF2 polyclonal Antibody | BS8236

NRBF2 polyclonal Antibody | BS8236 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200

Background: Nuclear hormone receptors function as transcriptional activators when their cognate ligands are bound. Binding of the appropriate ligand induces a conformational change in the nuclear receptor, allowing it to interact with transcriptional coactivators. NRBF2 (Nuclear receptor-binding factor 2), also known as COPR (Comodulator of PPAR and RXR), is thought to act as a transcriptional coactivator by altering the activity of target nuclear receptors. Highly expressed in the liver, placenta and keratinocytes, NRBF2 can interact with at least 7 nuclear receptors including PPARα, PPARδ and PPARγ. In the presence of a bound ligand, NRBF2 can interact with nuclear receptors RARα, RARγ. and RXRα. NRBF2, which exists as two isoforms due to alternative splicing, is localized to both the nucleus and the cytoplasm.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NRBF2 polyclonal Antibody detects endogenous levels of NRBF2 protein.

Molecular Weight: ~ 38 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Nuclear receptor-binding factor 2; NRBF-2; Comodulator of PPAR and RXR; NRBF2; COPR

Immunogen: Recombinant full length Human NRBF2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Regulation of Apoptosis,AMPK Signaling Pathway,