LBD
NRG3 Antibody (Center) [APR05721G]
- SKU:
- LBD-APR05721G
- Availability:
- Usually ships in 5 working days
Description
NRG3 Antibody (Center) [APR05721G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This NRG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-336 amino acids from the Central region of human NRG3.
Cellular Localisation: [Pro-neuregulin-3, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active. [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form
Molecular Weight: 77901
Clone: Polyclonal
Gene Name: NRG3
Gene ID: 10718
Function: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Summary: Tissue Location: Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IHC-P, WB
Dilution: WB--1:1000 IHC-P--1:100~500
Synonyms: Pro-neuregulin-3, membrane-bound isoform, Pro-NRG3, Neuregulin-3, NRG-3, NRG3