NS-1643 | B1138

NS-1643 is a hERG (Human ether-a-go-go related gene) K⁺channel activator with EC₅₀ of 10.5 μM. It shows antiarrhythmic activity in vitro and exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channel.

NS-1643 is a hERG (Human ether-a-go-go related gene) K⁺ channel activator with EC₅₀ of 10.5 μM. It shows antiarrhythmic activity in vitro and exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channel.

B1138 | NS-1643 DataSheet

Alternate Name/Synonyms: N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea

Appearance: Off White solid

Formulation: N/A

CAS Number: 448895-37-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₀F₆N₂O₃

Molecular Weight: 380.24

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>8 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A hERG K⁺ channel activator

MDL Number: MFCD08705418

PubChem CID: 10177784

SMILES: C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)O)O

InChi: 1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26)

InChi Key: NJFVQMRYJZHGME-UHFFFAOYSA-N