NSC 146109 hydrochloride | 1907

Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.

NSC 146109 is a p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes.

1907 | NSC 146109 hydrochloride DataSheet

Alternate Name/Synonyms: (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride; XI-011

Appearance: Yellow solid

Formulation: N/A

CAS Number: 59474-01-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₆N₂S.HCl

Molecular Weight: 316.85

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM) or EtOH (10 mM)

Handling: Protect from moisture

Country of Origin: USA

Tag Line: A p53 activator

MDL Number: N/A

PubChem CID: 16759161

SMILES: CC1=C2C=CC=CC2=C(C3=CC=CC=C13)CSC(=N)N.Cl

InChi: InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5- 3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H

InChi Key: VIBMUYOXJUCEMA-UHFFFAOYSA-N