NSC-23925 | 2686

NSC-23925 is a potent plasma membrane glycoprotein 1(Pgp1) inhibitor. It inhibits Pgp1 and reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR. NSC23925 directly inhibits the function of Pgp1 in a dose-dependent manner without altering the total expression level of Pgp1. NSC23925 stimulates ATPase activity of Pgp.

NSC-23925 is a potent plasma membrane glycoprotein 1(Pgp1) inhibitor. It inhibits Pgp1 and reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR. NSC23925 directly inhibits the function of Pgp1 in a dose-dependent manner without altering the total expression level of Pgp1. NSC23925 stimulates ATPase activity of Pgp.

2686 | NSC-23925 DataSheet

Alternate Name/Synonyms: 2-(p-Methoxyphenyl)-α-2-piperidyl-4-quinolinemethanol dihydrochloride, NSC-23925, [2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 858474-14-3

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₄N₂O₂ · 2HCl

Molecular Weight: 421.36

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: H₂O (~5 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent plasma membrane glycoprotein 1(Pgp1) inhibitor

MDL Number: MFCD22666390

PubChem CID: 54601129

SMILES: OC(C1NCCCC1)C2=CC(C3=CC=C(OC)C=C3)=NC4=CC=CC=C24.[H]Cl.[H]Cl

InChi: InChI=1S/C22H24N2O2.2ClH/c1-26-16-11-9-15(10-12-16)21-14-18(17-6-2-3-7-19(17)24-21)22(25)20-8-4-5-13-23-20;;/h2-3,6-7,9-12,14,20,22-23,25H,4-5,8,13H2,1H3;2*1H

InChi Key: WGWOQHWZXLGPNG-UHFFFAOYSA-N