NSC-59984 | B1052

NSC-59984 is a p53 pathway activator that induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC₅₀ of NSC-59984 in most cancer cells is significantly lower than those of normal cells, with EC₅₀ of 8.38 μM for p53- HCT116 cells. NSC-59984 induces p73-dependent cell apoptosis in cancer in vivo.

NSC-59984 is a p53 pathway activator that induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC₅₀ of NSC-59984 in most cancer cells is significantly lower than those of normal cells, with EC₅₀ of 8.38 μM for p53- HCT116 cells. NSC-59984 induces p73-dependent cell apoptosis in cancer in vivo.

B1052 | NSC-59984 DataSheet

Alternate Name/Synonyms: (E)-1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 803647-40-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₅N₃O₄

Molecular Weight: 265.27

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A p53 pathway activator

MDL Number: N/A

PubChem CID: 5356520

SMILES: CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-]

InChi: InChI=1S/C12H15N3O4/c1-13-6-8-14(9-7-13)11(16)4-2-10-3-5-12(19-10)15(17)18/h2-5H,6-9H2,1H3/b4-2+

InChi Key: QKTRIGNWBRHBFV-DUXPYHPUSA-N