NSC-617145 | B2664

NSC- 617145 is an inhibitor of Werner syndrome helicase (WRN) (IC₅₀ = 250 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only displaying 7% inhibition of RECQ1 at a concentration of 5 µM. It acts synergistically with Mitomycin C (Cat. No. 2713) to induce double-strand breaks and chromosomal abnormalities in vitro.

NSC- 617145 is an inhibitor of Werner syndrome helicase (WRN) (IC₅₀ = 250 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only displaying 7% inhibition of RECQ1 at a concentration of 5 µM. It acts synergistically with Mitomycin C (Cat. No. 2713) to induce double-strand breaks and chromosomal abnormalities in vitro.

B2664 | NSC-617145 DataSheet

Alternate Name/Synonyms: 1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione

Appearance: Off-white solid

Formulation:

CAS Number: 203115-63-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₀Cl₄N₂O₄

Molecular Weight: 400.04

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: ~8 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A Werner syndrome helicase (WRN) inhibitor

MDL Number:

PubChem CID: 357621

SMILES: CC(C)(CN1C(=O)C(=C(C1=O)Cl)Cl)CN2C(=O)C(=C(C2=O)Cl)Cl

InChi: InChI=1S/C13H10Cl4N2O4/c1-13(2,3-18-9(20)5(14)6(15)10(18)21)4-19-11(22)7(16)8(17)12(19)23/h3-4H2,1-2H3

InChi Key: PCOXPBOKDABARQ-UHFFFAOYSA-N