Description
NSC-663284 is a potent, selective and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC₅₀ = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively). Displays > 20- and > 450-fold selectivity over VHR and PTP1B phosphatases respectively. Arrests cells at both G1 and G2/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC₅₀ = 0.2 - 35 μM).
NSC-663284 is a potent, selective and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC₅₀ = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively). Displays > 20- and > 450-fold selectivity over VHR and PTP1B phosphatases respectively. Arrests cells at both G1 and G2/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC₅₀ = 0.2 - 35 μM).
Alternate Name/Synonyms: 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
Appearance: Red solid
Formulation: N/A
CAS Number: 383907-43-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₅H₁₆ClN₃O₃
Molecular Weight: 321.76
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (~15 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective Cdc25A inhibitor
MDL Number: MFCD08276924
PubChem CID: 379077
SMILES: C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl
InChi: InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
InChi Key: BMKPVDQDJQWBPD-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |