NSC 66811 | 2009

Cell-permeable. Potent MDM2 (murine double minute 2) inhibitor (Ki = 120 nM) that disrupts MDM2-p53 interaction and activates p53 in cancer cells. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.

NSC 66811 Potent MDM2 (murine double minute 2) inhibitor (Ki = 120 nM) that disrupts MDM2-p53 interaction and activates p53 in cancer cells. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.

2009 | NSC 66811 DataSheet

Alternate Name/Synonyms: 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol

Appearance: White solid

Formulation: N/A

CAS Number: 6964-62-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₀N₂O

Molecular Weight: 340.42

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (~ 100 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Potent MDM2 inhibitor

MDL Number: N/A

PubChem CID: 248986

SMILES: CC1=NC2=C(C=C1)C=CC(=C2O)C(C3=CC=CC=C3)NC4=CC=CC=C4

InChi: InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4- 2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3

InChi Key: WEENRMPCSWFMTE-UHFFFAOYSA-N