NSD1 / KMT3B monoclonal Antibody | MB0059

NSD1 / KMT3B monoclonal Antibody | MB0059 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Application: WB

Application Range: WB: 1:1000

Background: This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of NSD1 / KMT3B and does not cross-react with related proteins

Molecular Weight: Predicted band size:297KDa Observed band size:300KDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; Androgen receptor coactivator 267 kDa protein; Androgen receptor-associated protein of 267 kDa; H3-K36-HMTase; H4-K20-HMTase; Lysine N-methyltransferase 3B; Nuclear receptor-binding SET domain-containing protein 1; NR-binding SET domain-containing protein; NSD1; ARA267; KMT3B

Immunogen: Recombinant full length Human NSD1 / KMT3B.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A