NTN1 Antibody (C-term) [AMM06846G]

NTN1 Antibody (C-term) [AMM06846G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 568-596 amino acids from the C-terminal region of human NTN1.

Cellular Localisation: Secreted. Cytoplasm. Note=Mainly secreted

Molecular Weight: 67748

Clone: Polyclonal

Gene Name: NTN1

Gene ID: 9423

Function: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977) . Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977) . It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335) .

Summary: Tissue Location: Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Netrin-1, Epididymis tissue protein Li 131P, NTN1, NTN1L