NVP-231 | B2225

NVP-231 is a potent and reversible inhibitor of ceramide kinase (CerK) (IC₅₀ = 12 nM). It displays selectivity for CerK over sphingosine kinases (IC₅₀ ≥100 μM) and other lipid kinases.

NVP-231 is a potent and reversible inhibitor of ceramide kinase (CerK) (IC₅₀ = 12 nM). It displays selectivity for CerK over sphingosine kinases (IC₅₀ ≥100 μM) and other lipid kinases.

B2225 | NVP-231 DataSheet

Alternate Name/Synonyms: N -[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 362003-83-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₅N₃O₂S

Molecular Weight: 431.55

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and reversible ceramide kinase (CerK) inhibitor

MDL Number: N/A

PubChem CID: 4096211

SMILES: C1C2CC3CC1CC(C2)(C3)C(=O)NC4=CC5=C(C=C4)N=C(S5)NC(=O)C6=CC=CC=C6

InChi: InChI=1S/C25H25N3O2S/c29-22(18-4-2-1-3-5-18)28-24-27-20-7-6-19(11-21(20)31-24)26-23(30)25-12-15-8-16(13-25)10-17(9-15)14-25/h1-7,11,15-17H,8-10,12-14H2,(H,26,30)(H,27,28,29)

InChi Key: MVSSJPGNLQPWSW-UHFFFAOYSA-N