Description
NVP-231 is a potent and reversible inhibitor of ceramide kinase (CerK) (IC₅₀ = 12 nM). It displays selectivity for CerK over sphingosine kinases (IC₅₀ ≥100 μM) and other lipid kinases.
NVP-231 is a potent and reversible inhibitor of ceramide kinase (CerK) (IC₅₀ = 12 nM). It displays selectivity for CerK over sphingosine kinases (IC₅₀ ≥100 μM) and other lipid kinases.
Alternate Name/Synonyms: N -[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 362003-83-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₂₅N₃O₂S
Molecular Weight: 431.55
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and reversible ceramide kinase (CerK) inhibitor
MDL Number: N/A
PubChem CID: 4096211
SMILES: C1C2CC3CC1CC(C2)(C3)C(=O)NC4=CC5=C(C=C4)N=C(S5)NC(=O)C6=CC=CC=C6
InChi: InChI=1S/C25H25N3O2S/c29-22(18-4-2-1-3-5-18)28-24-27-20-7-6-19(11-21(20)31-24)26-23(30)25-12-15-8-16(13-25)10-17(9-15)14-25/h1-7,11,15-17H,8-10,12-14H2,(H,26,30)(H,27,28,29)
InChi Key: MVSSJPGNLQPWSW-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |