Description
A Hsp90 inhibitor. NVP-AUY922 has excellent potency against Hsp90 in a fluorescence polarization binding assay with an IC₅₀ of 21 nmol/L against the β-isoform and of 13 nmol/L for the α-isoform.
NVP-Auy922 is a Hsp90 inhibitor. NVP-AUY922 has excellent potency against Hsp90 in a fluorescence polarization binding assay with an IC₅₀ of 21 nmol/L against the β-isoform and of 13 nmol/L for the α-isoform.
Alternate Name/Synonyms: 5-(2,4-Dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 747412-49-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₃₁N₃O₆
Molecular Weight: 465.54
Cell-Permeable?: Yes
Purity: ≥99%
Solubilities: DMSO (10 mM)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A Hsp90 inhibitor
MDL Number: N/A
PubChem CID: 10096043
SMILES: CCNC(=O)C1=C(C(=C2C=C(C(=CC2=O)O)C(C)C)ON1)C3=CC=C(C=C3)CN4CCOCC4
InChi: InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33- 12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,28, 30H,4,9-12,15H2,1-3H3,(H,27,32)/b25-20-
InChi Key: SWDZPNJZKUGIIH-QQTULTPQSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24months |
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