Nystatin, USP | B1509

Nystatin is a polyene antifungal antibiotic produced by Streptomyces noursei. Nystatin acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating nystatin/ergosterol based ion channels. It also functions as a lipid raft-inhibiting reagent and as membrane associated cholesterol.

Nystatin is a polyene antifungal antibiotic produced by Streptomyces noursei. Nystatin acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating nystatin/ergosterol based ion channels. It also functions as a lipid raft-inhibiting reagent and as membrane associated cholesterol.

B1509 | Nystatin, USP DataSheet

Alternate Name/Synonyms: Fungicidin, Mycostatin

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1400-61-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₄₇H₇₅NO₁₇

Molecular Weight: 926.1

Cell-Permeable?: Yes

Purity: Potency: ≥4400 U/mg

Solubilities: DMSO (~ 5 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A polyene antifungal antibiotic

MDL Number: MFCD25541651

PubChem CID: 6433272

SMILES: CC1C=CC=CCCC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(C(CCC(CC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O

InChi: InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1

InChi Key: VQOXZBDYSJBXMA-RKEBNKJGSA-N