ODM-201 | 9668

ODM-201 is a new-generation, potent and selective androgen receptor (AR) antagonist (Ki = 11 nM). In AR overexpressing HS-HEK293 cells, ODM-201 inhibits the androgen-induced nuclear translocation of overexpressed AR. In the VCaP cell line with endogenous AR gene amplification and AR overexpression, ODM-201 inhibits androgen-induced cell proliferation with IC₅₀ value of 230 nM.

ODM-201 is a new-generation, potent and selective androgen receptor (AR) antagonist (Ki = 11 nM). In AR overexpressing HS-HEK293 cells, ODM-201 inhibits the androgen-induced nuclear translocation of overexpressed AR. In the VCaP cell line with endogenous AR gene amplification and AR overexpression, ODM-201 inhibits androgen-induced cell proliferation with IC₅₀ value of 230 nM.

9668 | ODM-201 DataSheet

Alternate Name/Synonyms: N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide

Appearance: Whte to off-white solid

Formulation: N/A

CAS Number: 1297538-32-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₉ClN₆O₂

Molecular Weight: 389.85

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A new-generation, potent and selective androgen receptor (AR) antagonist

MDL Number: N/A

PubChem CID: 67171867

SMILES: CC(CN1C=CC(=N1)C2=CC(=C(C=C2)C#N)Cl)NC(=O)C3=NNC(=C3)C(C)O

InChi: InChI=1S/C19H19ClN6O2/c1-11(22-19(28)18-8-17(12(2)27)23-24-18)10-26-6-5-16(25-26)13-3-4-14(9-21)15(20)7-13/h3-8,11-12,27H,10H2,1-2H3,(H,22,28)(H,23,24)/t11-,12?/m0/s1

InChi Key: BLIJXOOIHRSQRB-PXYINDEMSA-N