OF-1 | 9592

OF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (Kd values are 100 and 500 nM respectively). OF-1 displays 39-fold selectivity for BRPF1B and BRPF2 over BRD4. It increases thermal stability of full length BRPF1B at 1 µM, in the cellular thermal shift assay. It also demonstrates accelerated fluorescence recovery after photobleaching (FRAP) at 5 µM in the BRPF2 FRAP assay. OF-1 displays modest general cytotoxicity.

OF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (Kd values are 100 and 500 nM respectively). OF-1 displays 39-fold selectivity for BRPF1B and BRPF2 over BRD4. It increases thermal stability of full length BRPF1B at 1 µM, in the cellular thermal shift assay. It also demonstrates accelerated fluorescence recovery after photobleaching (FRAP) at 5 µM in the BRPF2 FRAP assay. OF-1 displays modest general cytotoxicity.

9592 | OF-1 DataSheet

Alternate Name/Synonyms: 4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide

Appearance: Beige solid

Formulation: N/A

CAS Number: 919973-83-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₈BrN₃O₄S

Molecular Weight: 440.31

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>8 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective BRPF1B and BRPF2 bromodomain inhibitor

MDL Number: N/A

PubChem CID: 35397514

SMILES: CC1=C(C=CC(=C1)Br)S(=O)(=O)NC2=C(C=C3C(=C2)N(C(=O)N3C)C)OC

InChi: InChI=1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3

InChi Key: YUNQZQREIHWDQT-UHFFFAOYSA-N