OGDH polyclonal Antibody | BS8180

OGDH polyclonal Antibody | BS8180 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: The α-ketoglutarate dehydrogenase (α-KGD) complex is a multienzyme complex which localizes to the mitochondrial matrix and consists of three protein subunits: α-ketoglutarate dehydrogenase, also designated α-KGD, E1k or oxoglutarate dehydrogenase (OGDH) ; dihydrolipoyl succinyltransferase (E2k or DLST) ; and dihydrolipoyl dehydrogenase (E3) . The α-KGD subunit of the α-KGD complex catalyzes the conversion of α-ketoglutarate to succinyl-CoA and CO2, an essential reaction of the tricarboxylic acid cycle. A definciency in α-KGD results in hypotonia, metabolic acidosis, hyperlactatemia immediately after birth, and neurologic deterioration resulting in death at about 30 months of age. Low molar ratios of ketone bodies in plasma of neonates with congenital lactic acidosis are proposed indicators of tricarboxylic acid cycle dysfunction.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: OGDH polyclonal Antibody detects endogenous levels of OGDH protein.

Molecular Weight: ~ 116 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: 2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase; OGDH

Immunogen: Recombinant full length Human OGDH.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: