Olanzapine | B2677

Olanzapine is an antipsychotic agent with anticholinergic properties. It binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57 nM, respectively). It also binds to M1 muscarinic acetylcholine, α1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively). Olanzapine induces autophagy, mitochondrial damage and mitophagy in human SH-SY5Y neuronal cell line.

Olanzapine is an antipsychotic agent with anticholinergic properties. It binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57 nM, respectively). It also binds to M1 muscarinic acetylcholine, α1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively). Olanzapine induces autophagy, mitochondrial damage and mitophagy in human SH-SY5Y neuronal cell line.

B2677 | Olanzapine DataSheet

Alternate Name/Synonyms: LY170053,2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

Appearance: Yellow solid

Formulation:

CAS Number: 132539-06-1

Structure Available?: Yes

Peptide sequence:

Salt Form: No

Molecular Formula: C₁₇H₂₀N₄S

Molecular Weight: 312.43

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~15 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antipsychotic agent with anticholinergic properties

MDL Number: MFCD00866702

PubChem CID: 135398745

SMILES: CN(CC1)CCN1C2=NC3=CC=CC=C3NC4=C2C=C(C)S4

InChi: InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3

InChi Key: KVWDHTXUZHCGIO-UHFFFAOYSA-N