Olaparib | 1952

Cell-permeable. A highly potent and selective PARP-inhibitor with IC₅₀ values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively. Olaparib displays standalone activity in BRCA-1 deficient breast cancer cells.

Olaparib is a highly potent and selective PARP-inhibitor with IC₅₀ values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively. Olaparib displays standalone activity in BRCA-1 deficient breast cancer cells.

1952 | Olaparib DataSheet

Alternate Name/Synonyms: 4-(3-(4-(cycloprppanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(2H)-one; ADZ-2281; KU-59436

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 763113-22-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₃FN₄O₃

Molecular Weight: 434.46

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~33 mg/ml) or EtOH (~ 1.7 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A highly potent and selective PARP-inhibitor

MDL Number: MFCD13185161

PubChem CID: 23725625

SMILES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

InChi: InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26- 21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7, 9-12,14H2,(H,27,30)

InChi Key: FDLYAMZZIXQODN-UHFFFAOYSA-N