Description
Cell-permeable. A highly potent and selective PARP-inhibitor with IC₅₀ values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively. Olaparib displays standalone activity in BRCA-1 deficient breast cancer cells.
Olaparib is a highly potent and selective PARP-inhibitor with IC₅₀ values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively. Olaparib displays standalone activity in BRCA-1 deficient breast cancer cells.
Alternate Name/Synonyms: 4-(3-(4-(cycloprppanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(2H)-one; ADZ-2281; KU-59436
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 763113-22-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₃FN₄O₃
Molecular Weight: 434.46
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~33 mg/ml) or EtOH (~ 1.7 mg/ml)
Handling: Protect from light and air
Country of Origin: USA
Tag Line: A highly potent and selective PARP-inhibitor
MDL Number: MFCD13185161
PubChem CID: 23725625
SMILES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
InChi: InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26- 21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7, 9-12,14H2,(H,27,30)
InChi Key: FDLYAMZZIXQODN-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
48 months |