Description
ONC212 is a fluorinated imipridone analogue of ONC201. It is an activator of GPCR GPR132 and Gαq signaling, which functions as a tumor suppressor. It induces apoptosis in HPAF-II and AsPC1 cell lines at 20 μM and potently prevents colony formation at 5 μM in HPAF-II cells. It inhibits acute myeloid leukemia growth in vivo and improves overall survival in xenografted mice.
ONC212 is a fluorinated imipridone analogue of ONC201. It is an activator of GPCR GPR132 and Gαq signaling, which functions as a tumor suppressor. It induces apoptosis in HPAF-II and AsPC1 cell lines at 20 μM and potently prevents colony formation at 5 μM in HPAF-II cells. It inhibits acute myeloid leukemia growth in vivo and improves overall survival in xenografted mice.
Alternate Name/Synonyms: 11-benzyl-7-[[4-(trifluoromethyl)phenyl]methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one
Appearance: Solid
Formulation:
CAS Number: 1807861-48-8
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₂₄H₂₃F₃N₄O
Molecular Weight: 440.46
Cell-Permeable?: True
Purity: 99.20%
Solubilities: 50 mg/ml in DMSO (need ultrasonication) in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A selective agonist of GPR132 with anti-cancer activity
MDL Number:
PubChem CID: 124085867
SMILES: C1CN(CC2=C1N3CCN=C3N(C2=O)CC4=CC=C(C=C4)C(F)(F)F)CC5=CC=CC=C5
InChi: InChI=1S/C24H23F3N4O/c25-24(26,27)19-8-6-18(7-9-19)15-31-22(32)20-16-29(14-17-4-2-1-3-5-17)12-10-21(20)30-13-11-28-23(30)31/h1-9H,10-16H2
InChi Key: DFULPGUTXZTYKA-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |
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