Opicapone | B3107

Opicapone is a potent inhibitor of catechol-O-methyltransferase (COMT). It inhibits rat peripheral COMT with ED₅₀ values below 1.4 mg/kg up to 6 h post-administration. It is approved for use as adjunctive treatment to levodopa/carbidopa in patients with Parkinson’s disease.

Opicapone is a potent inhibitor of catechol-O-methyltransferase (COMT). It inhibits rat peripheral COMT with ED₅₀ values below 1.4 mg/kg up to 6 h post-administration. It is approved for use as adjunctive treatment to levodopa/carbidopa in patients with Parkinson’s disease.

B3107 | Opicapone DataSheet

Alternate Name/Synonyms: BIA 9-1067; 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxidopyridin-1-ium-3-yl)-1,2,4-oxadiazol-5-yl]-3-nitrobenzene-1,2-diol; 2,5-Dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide; (4Z)-4-[3-(2,5-dichloro-4,6-dimethyl-1-oxidopyridin-1-ium-3-yl)-2H-1,2,4-oxadiazol-5-ylidene]-2-hydroxy-6-nitrocyclohexa-2,5-dien-1-one

Appearance: Powder

Formulation:

CAS Number: 923287-50-7

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₅H₁₀Cl₂N₄O₆

Molecular Weight: 413.2

Cell-Permeable?: True

Purity: ≥ 98%

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent inhibitor of catechol-O-methyltransferase

MDL Number: MFCD19443745

PubChem CID: 135565903

SMILES: CC1=C(C(=[N+](C(=C1Cl)C)[O-])Cl)C2=NOC(=N2)C3=CC(=C(C(=C3)O)O)[N+](=O)[O-]

InChi: InChI=1S/C15H10Cl2N4O6/c1-5-10(13(17)20(24)6(2)11(5)16)14-18-15(27-19-14)7-3-8(21(25)26)12(23)9(22)4-7/h3-4,22-23H,1-2H3

InChi Key: ASOADIZOVZTJSR-UHFFFAOYSA-N